Everything listed here is Research Use Only (RUO). Not for human or animal consumption.
A nonapeptide originally isolated from rabbit cerebral venous blood during induced sleep. Studies have investigated its effects on sleep architecture, stress modulation, and neuroendocrine regulation.
Delta Sleep-Inducing Peptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) is a naturally occurring nonapeptide identified by Schoenenberger and Monnier in 1977. Despite its name, its effects on sleep are more nuanced than simple sleep induction. DSIP modulates sleep architecture by promoting delta wave (slow-wave) sleep patterns and normalizing disturbed sleep-wake cycles. Its mechanisms include modulation of GABA-ergic and glutamatergic signaling, reduction of corticotropin release during stress, and interaction with opioid systems. DSIP also influences LH release, somatostatin levels, and has been shown to have analgesic and antioxidant properties. It readily crosses the blood-brain barrier.
Graf MV, Kastin AJ. Delta-sleep-inducing peptide (DSIP): a review. Neurosci Biobehav Rev. 1984;8(1):83-93.
Key finding: Comprehensive review of DSIP pharmacology establishing its effects on sleep architecture, stress responses, and neuroendocrine function, while noting that its sleep-promoting effects are modulatory rather than hypnotic.
Mikhaleva II, et al. Interaction of delta sleep-inducing peptide and its analogues with cellular membranes: a structure-function analysis. Bioorg Khim. 2006;32(2):176-182.
Key finding: Compared DSIP with synthetic analogues to identify which residues govern its interaction with cell membranes.
| Type | Peptide (nonapeptide) |
Research Use Only (RUO): This page summarizes published scientific research and is provided for educational and informational purposes only. It is not intended as medical advice, diagnosis, or treatment recommendations. The compound described carries a Research Use Only designation and is intended for laboratory research use only. It is not intended for human or animal consumption, or for use in the diagnosis, treatment, cure, or prevention of any disease. Consult qualified professionals before making any health-related decisions.