Everything listed here is Research Use Only (RUO). Not for human or animal consumption.
A pro-apoptotic peptidomimetic that targets the vascular supply of white adipose tissue. Primate studies have investigated selective ablation of adipose vasculature and its effects on adipose tissue metabolism.
Adipotide (FTPP — Prohibitin Targeting Peptide 1) is a chimeric peptide composed of two functional domains: a targeting sequence that binds to prohibitin on the surface of blood vessels supplying white adipose tissue, and a pro-apoptotic sequence (D(KLAKLAK)2) that disrupts mitochondrial membranes upon internalization. By selectively inducing apoptosis in the endothelial cells of the adipose vasculature, adipotide causes ischemic changes in adipocytes, resulting in measurable alterations in adipose tissue composition. This vascular-targeting approach bypasses traditional metabolic pathways entirely.
Barnhart KF, et al. A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys. Sci Transl Med. 2011;3(108):108ra112.
Key finding: Research investigated the effects of adipotide on adipose vasculature remodeling in obese rhesus monkeys, observing changes in body composition and insulin signaling pathways over a 4-week period.
Kolonin MG, et al. Reversal of obesity by targeted ablation of adipose tissue. Nat Med. 2004;10(6):625-632.
Key finding: Demonstrated that targeting the vascular supply of adipose tissue with a pro-apoptotic peptide could modulate adipose tissue composition in mouse models through vascular remodeling mechanisms.
Research Use Only (RUO): This page summarizes published scientific research and is provided for educational and informational purposes only. It is not intended as medical advice, diagnosis, or treatment recommendations. The compound described carries a Research Use Only designation and is intended for laboratory research use only. It is not intended for human or animal consumption, or for use in the diagnosis, treatment, cure, or prevention of any disease. Consult qualified professionals before making any health-related decisions.